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One study reported that the depletion of APP using siRNA or antibodies in vivo reduced long-term potentiation (LTP) in mouse brains, crucial to memory formation, that could be rescued by the addition of exogenous human A 142 (Puzzo et al., 2011)
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While its true that receptor density can change due to various factors, its an oversimplification to suggest that this change is the direct cause of increased pain or sensations in B12-treated individuals
J Neuroimmunol
Signs you may need to reduce dose include persistent headaches, unusual fatigue, or injection site reactions that worsen over time
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