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To explore whether LS GLP-1R neuronal activity acts as negative or positive valence, we implemented optogenetic activation by expressing channelrhodopsin (ChR2-mCherry) selectively in LS GLP-1R neurons (Figure 5I)
You must still focus on eating healthy foods and moving your body
10.1016/S0006-3223(01)01211-2 24 BissetteG.NemeroffC
Using much smaller amounts than clinical doses to test personal tolerance and reduce side effects
2.4 Implications for drug discovery strategy Recognizing underexploration as a product of historical context rather than biological inadequacy has important implications for drug discovery strategy
Dual action = deeper appetite control and better metabolic profile
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