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Common side effects include nausea, vomiting, diarrhea, and constipation, which often subside as the body adjusts to the medication

This occurs because the pituitary gland and adipose tissue are stimulated to produce androgens and luteinizing hormone, respectively, in response to increasing levels of androgens, which in turn heighten insulin resistance (IR) and hyperinsulinemia (Hg)

11 Vildagliptin is particularly useful in older patients, either combined with metformin or alone if metformin is contraindicated or not tolerated

In the middle is the FDA trying to referee the high-stakes and increasingly contentious battle

They can take time to feel, and the effects can last longer than someone expects