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In the technical scheme of the invention, the coupling of the ionic liquid Linker to the solid-phase resin comprises the following steps: step one, reacting 1- (2-hydroxyethyl) imidazole or 1- (3-hydroxypropyl) -1H-imidazole with isobutene, extracting and crystallizing to obtain tert-butyl protected 1- (2-hydroxyethyl) imidazole or 1- (3-hydroxypropyl) -1H-imidazole

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When combining the two, expect nausea to be most pronounced during dose escalation periods, particularly when both compounds are being increased in close succession