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Gut-brain peptides have different functions when administered into the brain relative to the periphery since the blood-brain barrier (BBB) restricts access of peripheral peptides to the CNS
The main exception is bupropion, which tends to be weight-favourable, and is one of the two ingredients in Contrave
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Janus kinase (JAK) inhibitors represent newer targeted synthetic DMARDs with demonstrated efficacy, though they carry boxed warnings regarding serious infections, malignancy, major adverse cardiovascular events, and thrombosis
Compounded semaglutide has also emerged as an access pathway within licensed medical programs, particularly in response to supply constraints and cost considerations
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