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The evidence provided in these papers is stronger for dopamine-related reward modulation than for direct serotonin-mediated mood effects

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Your GP or diabetes specialist should: Evaluate whether symptoms coincide with dose escalation (suggesting a possible connection to treatment) Review all concurrent medications for potential contributors Assess for alternative causes, particularly thyroid function and menopausal status in women Consider whether glycaemic control has changed significantly Review insulin or sulfonylurea doses if hypoglycaemia is suspected For women experiencing menopausal hot flushes, hormone replacement therapy (HRT) is generally considered first-line treatment where appropriate, in line with NICE guidance

Tirzepatide (Zepbound, Mounjaro) Tirzepatide is a dual agonist targeting both GLP-1 and GIP receptors

*Correspondence: Shaobin Wei [email protected] These authors have contributed equally to this work These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers