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2019;98(27):e16308
Conversely, the same analysis found no difference in weight loss for exenatide once weekly or liraglutide between patients experiencing gastrointestinal adverse events and those with none in DURATION-6 [52]
For instance, intranasal insulin has been widely studied for its ability to bypass the blood-brain barrier and achieve systemic effects, demonstrating the nasal routes viability for peptide absorption when combined with permeation enhancers and mucoadhesive agents
DOI: 10.1111/crj.13372 [Google Scholar] Yu M, Wang R, Pei L, Zhang X, Wei J, Wen Y, et al
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Common side effects include: nausea vomiting diarrhoea constipation abdominal discomfort bloating reduced appetite acid reflux Most symptoms occur: during dose escalation within the first few weeks after dose increases They are usually mild to moderate and often improve as the body adapts, particularly when doses are increased gradually under clinical supervision
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