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Deficiency of Trem2 in macrophages worsens lipid accumulation and ferroptosis in TECs via IL-1-dependent CD36 upregulation, thus promoting DKD progression (201)

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Drugs of this class used in obesity are commonly known as "anorectics" or "anorexigenics." The effect of phentermine on weight reduction and long-term maintenance of body weight is likely mediated by release of catecholamines in the hypothalamus, resulting in reduced appetite and decreased food consumption, but other metabolic effects may also be involved