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The short-acting preparation of GLP-1RA mainly reduces postprandial blood glucose by delaying gastric emptying and increasing insulin secretion (28, 59)

Yes, gastrointestinal side effects of semaglutide such as nausea, vomiting, and diarrhea can lead to dehydration and volume depletion, which may cause compensatory increases in heart rate that patients perceive as palpitations

Two honest notes

Many Aetna commercial group plans do cover weight loss medication including GLP-1 agonists for patients meeting BMI criteria

Tirzepatide is provided for scientific research only

Some patients find that injecting the medication on a specific day of the week when they have fewer obligations allows them to rest if nausea occurs