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Recognition of double-stranded RNA and activation of NF-B by Toll-like receptor 3

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While eumelanin shows photoprotective capacity against ultraviolet (UV) [15], in contrast pheomelanin is weakly photoprotective and highly phototoxic, enhancing the UV-induced production of reactive oxygen species (ROS) and further damage of cells [16]

Accordingly, elevations in 6-phosphogluconolactone, 6-phosphogluconate, and sedoheptulose 7-phosphate are observed in this same group as a function of storage time and additives (highest in E-Sol5 RBCs at +4 C Fig