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For patients trying to conceive, they are advised to continue using contraception for a defined wash-out period, i.e

In both male and female GHRKO mice, disruption of the GH/IGF-1 axis from birth results in mice that are remarkably long lived, but temporal disruption of this pathway in young adults (aGHRKO mice) improves lifespan only in females 17 , an observation which is consistent with the beneficial effects of targeting IGF-1R signaling post-development on female healthspan and aging in this study

No increase in dose-dependent gastrointestinal adverse events was observed

Prescribing it primarily for weight loss in a patient without type 2 diabetes is off-label use