Yes, B12 injections are generally considered very safe with minimal side effects
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The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)
Because the treatment delivers nutrients directly into the bloodstream, absorption is far more complete than anything a cream can achieve through the skin barrier, which translates to more even brightening from within
They are related to nervous system conditions, but they differ in nature
Scientific references The following are independent, peer-reviewed publications provided for reference