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J Biol Chem 282 , 2041620424, (2007)
This can lead to further accumulation of toxins, which can cause further damage to DNA and other cellular components
While the most concerning part of the FDA statement is its mention of APIs, it seems to primarily be focused on marketing
The cardiovascular indication added in 2024 has separate, looser criteria: established CVD (prior MI, ischemic stroke, or symptomatic PAD) plus BMI of 27 or higher
Some capsular fibrosis and periportal fibrosis may be present
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