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The Seven Biomarkers According to Smart Vascular Dx, the PULS Test evaluates the following key biomarkers: IL-16 (Interleukin-16) Signals T-cellmediated inflammation sFas (Soluble Fas) Marker of apoptotic regulation in vascular cells Fas Ligand Indicates immune-related endothelial damage HGF (Hepatocyte Growth Factor) Associated with endothelial repair Eotaxin Correlates with eosinophil-mediated inflammation CTACK (Cutaneous T-cellAttracting Chemokine) Marker of T-cell activation MCP-3 (Monocyte Chemotactic Protein-3) Involved in leukocyte trafficking These biomarkers have been validated in multiple studies to correlate with the progression and destabilization of atherosclerotic plaques

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The optimal dosing strategy requires pharmacokinetic studies in human subjects across body weight ranges to establish exposure-response relationships

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