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Although all unimolecular triple agonists in phase 2 trials for obesity are GLP1/GIP/GCG triple agonists, there is an ongoing phase 2 clinical trial of bioglutide, an oral insulin-like-growth factor-1 (IGF-1)/GLP-1/GIP/GCG quadruple agonist (NCT06564753) for individuals with obesity, which is also being trialled in combination with tirzepatide (NCT06643728)
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NAC-based drugs can also break up mucus in the lungs and airways
They work best when combined with a healthy diet and regular exercise, and should be positioned as complements to lifestyle change rather than replacements for it
These drugs are new to us, but theyve been at least a decade in development for diabetes, says Katrina Bicknell, professor of pharmacology and pharmacy education at Reading School of Pharmacy
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