Many people tolerate them well, but the IV route carries higher risks, including infection and severe allergic reactions
This supports a model in which CHAC1-mediated GSH depletion destabilizes NRF2 and reduces cystine import, allowing iron-dependent lipid peroxides to accumulate and trigger ferroptosis
10.1186/2191-219X-3-35 EJNMMI Res
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The full Phase 3 clinical-trial results should provide a clearer picture soon, but one noteworthy finding so far is dysesthesia, or odd sensations in the skin, such as burning and pain, that suggest unrest in the nervous system