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Many women notice changes such as: Slower metabolism and increased fat storage, especially around the belly and hips Changes in insulin sensitivity and blood sugar regulation Shifts in hunger and fullness signals Hormone fluctuations in perimenopause can trigger fat-storage mechanisms, reduce lean muscle mass, and make traditional diet and exercise feel less effective

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Its small size may support skin penetration, although this also depends heavily on the overall formulation and delivery system

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Advisory meetings often include nuance: safety questions, evidence gaps, route concerns, dosing concerns, and requests for better data

This is the biggest update since this comparison was first written