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These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs

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Non-specific effects on brain health Besides the several neuroprotective mechanisms putatively assigned to GLP-1RAs (see figure 1 and the Mechanisms of neuroprotection section), their largest contribution to a healthy cognition might be due to non-brain-specific benefits on other health domains.17 We have already mentioned the connections between diabetes, obesity and major neurocognitive disorders, where GLP-1RAs may act fruitfully by breaking such instrumental links