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2ac) indicate that BAs, probably the FXR-antagonistic BAs, might contribute to the cell-nonautonomous regulation of GLP-1 production by T3
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Before the promising therapeutic impact of miRNA can be realized, there are several challenges to be addressed, which include but not limited to targeted delivery of oligonucleotides to specific organs, tissues and cell types, poor bioavailability, limited tissue permeability ( via imperfect matching with 3UTRs ( REGULATION OF miRNA EXPRESSION Recently emerged question is how miRNAs are regulated under certain condition such as diseases