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Some patients on GLP-1 meds begin to lose weight right away, while others dont start losing until the dose is increased

To confirm the effect of GLP-1R and PI3K/Akt in CM, a GLP-1R selective agonist (liraglutide) and antagonist (exendin(939)) and a PI3K selective antagonist (LY294002) were administered

While GLP-1 receptors are expressed in hypothalamic and reproductive pathways, human data do not demonstrate direct infertility effects

We observed, that patients who developed PHLF displayed 2.3-fold higher GLP-1 plasma concentrations preoperatively, compared to patients without PHLF ( p = 0.030)

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