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Excessive peritoneal iron accumulation leads to overproduction of reactive oxygen species (ROS)-a group of highly reactive chemicals formed from oxygen, which at high concentrations can damage DNA, RNA, proteins, and lipids within the cell (20)-and enhanced activation of nuclear factor kappa-B (NF-B), which, by promoting the expression of matrix metalloproteinases (MMPs), exacerbates inflammation, angiogenesis, and cell adhesion
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These medicines include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro), which is a dual GIP/GLP-1 receptor agonist rather than a pure GLP-1 agonist
A 2023 retrospective cohort study found semaglutide significantly reduced binge eating episodes in patients with BED the first study of its kind A 2020 pilot study of dulaglutide found it reduced binge episodes in patients with type 2 diabetes and BED A 2026 meta-analysis found liraglutide reduced binge frequency by approximately 1.28 fewer episodes per week compared to placebo A rapid review of 25 studies encompassing over 8,700 adult patients found that binge eating episodes and prevalence reduced following liraglutide and semaglutide An observational study of 69 people with obesity found emotional eating dropped from 72.5% to 11.5% after three months of semaglutide The Critical Caveats Despite a promising early signal, these findings should be held carefully
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