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Interestingly, one study found that GLP-1R knockout mice were protected from high-fat diet-induced insulin resistance and had enhanced insulin-stimulated skeletal muscle glucose uptake, and these mice also exhibited enhanced action of insulin on hepatocytes as well as decreased hepatic and skeletal muscle triglyceride accumulation

Data analysis A population-based pharmacovigilance study utilizing a case/non-case approach was employed to investigate the potential association between GLP-1RA and reports of suicidal tendencies and/or self-injury

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It is currently in Phase 3 clinical trials, and approval is not expected for at least another 1-2 years at the earliest

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Ethical approval The studys experimental procedures were sanctioned by Cairo Universitys Institutional Animal Care and Use Committee (IACUC) within the Faculty of Science in Egypt, assigned the reference number CU/I/F/28/23