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In the skin, as in the bone, aromatase expression is driven by the glucocorticoid responsive distal promoter I.4 [61]
However, substantial evidence supports combining GLP-1 receptor agonists with testosterone therapy, and this data likely applies to Retatrutide given its shared mechanisms
In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks
PMID: 36 Wills-KarpM
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They are not a substitute for nutrition, activity, or medication review, but they can fit into a supervised program when the provider feels they are appropriate
