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Once the xenograft tumors for the study of 2DG or BPTES treatment were established (when the tumor volume was ~50100 mm 3 ), the mice were randomly divided into six groups ( n = 5 mice per group) and treated with saline buffer (10% DMSO), 2DG (500 mg/kg/day) or BPTES (12.5 mg/kg/day), each with or without TRAIL (5 g/kg/day), via intraperitoneal injection three times a week for 33 days

These deficits, even when localized to higher frequencies, can induce compensatory plasticity within central auditory circuits extending beyond the original site of damage, producing percepts at dissociated frequencies 7,10,11

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The process is quick and virtually painless, with minimal discomfort reported by most patients

2 Antidepressant mechanism of natural plant polysaccharides Polysaccharides in natural plant sources alleviate depression by regulating the expression of neurotransmitters and their receptors, HPA axis, neurotrophic factors, neuroinflammatory, oxidative stress, tryptophan metabolism and gut microbiota