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Some studies indicate that the risk is also due to higher homocysteine levels[ref], while other studies show that it may be due to the methylation of certain genes.[ref] Meta-analyses showed that the MTHFR C677T variant increased the risk of migraines with aura for all population ancestry groups

O'Dwyer PJ, LaCreta F, Nash S, Tinsley PW, Schilder R, Clapper ML, Tew KD, Panting L, Litwin S and Comis RL (1991)

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Ma B, Hottiger MO (2016) Crosstalk between Wnt/-catenin and NF-B signaling pathway during inflammation

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Cytokines (IL-15, IL-21, and IFN-) in Rheumatoid Arthritis: Association With Positivity to Autoantibodies (RF, Anti-CCP, Anti-MCV, and Anti-PADI4) and Clinical Activity