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Common effects usually mild and often worst during titration include nausea, vomiting, diarrhea, constipation, abdominal pain, upset stomach, headache, and fatigue

These effects were dose-dependent, meaning the higher the starting dose, the worse the symptoms

Toxicol Appl Pharmacol 242 ,241-246 (2010)

In a recent late-stage clinical trial, people who switched from weekly injectable GLP-1 drugs such as Wegovy or Zepbound to the experimental daily GLP-1 pill orforglipron maintained nearly all the weight loss they experienced over one year

Table 1 Changes of gut microbiota in patients with hypothyroidism

"FDA-approved compounded" or "same as Wegovy" is factually wrong