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First is to improve upstream pathways such as methylation

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The work, which used the protein insulin-like growth factor-1 (IGF-1), showed that an orally delivered, shelf-stable medication grown in lettuce plants could stimulate the growth of bone-building cells and promote bone regeneration

Concentrations naturally decline with age (from about 200 ng/mL at age 20 to 80 ng/mL by age 60), which is part of why supplementation makes sense

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