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In addition, we will highlight critical knowledge gaps, pertinent challenges, and potential therapeutic targets warranting future exploration to guide mechanistic and outcomes research
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Lean subjects: low NNMT activity in adipose tissue
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For instance, psychological stress activates the hypothalamicpituitaryadrenal (HPA) axis and sympathetic nerves, leading to cortisol and catecholamine release that increases intestinal permeability and disrupts the gut habitat [14, 15]
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