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GLP-1 receptor agonists such as Saxenda and Wegovy work, with clinical trial evidence behind them roughly 6% and 16% body weight reduction respectively over 68-week trials

Double dosing may be allowed, if approved by a doctor

Single-cell, omics studies of human L-cells, which secrete GLP-1 and 2, may uncover regulatory networks controlling incretin secretion

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Nrgaard CH, Friedrich S, Hansen CT, Gerds T, Ballard C, Mller DV, et al

An EKG ensures safe prescribing and monitoring