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[114] [115] Generally speaking, mild cases can cause few symptoms and either need no treatment or can be managed by means of avoiding circumstances which might trigger a crisis, monitoring and occasional treatment
doi: 10.1038/s41598-022-20519-7 127 KalmarB.LuC.-H.GreensmithL
That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route
Novel and reported variants in Parkinsons disease genes confer high disease burden among Indians
Once that date passes, the product does not suddenly become "bad," but the structural integrity of the protein may begin to shift
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