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Overall, her research suggests that tirzepatide increased insulin sensitivity both independently and as a function of weight

They are practical observations

In the phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), participants receiving higher doses of retatrutide achieved mean weight reductions of up to 17.5% of body weight over 24 weeks, with greater losses reported at 48 weeks

This isn't just a small dip

An explanation of how we came to these new recommendations can be found in Vitamin B12: Rationale for Recommendations

This neuroinflammatory response not only contributes to disease progression, but also amplifies damage initiated by other pathological processes, such as protein aggregation, mitochondrial dysfunction, and synaptic failure