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10.1371/journal.pone.0061965 PLoS One

Bottom line: biology isnt destiny, but it matters

Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

It creates profound hormonal and metabolic changes involving ghrelin, GLP-1, peptide YY, insulin sensitivity, bile acid metabolism, gut microbiota, and appetite regulation

Eur Biophys J

Tirzepatide has demonstrated cardiovascular safety with potential benefits including modest blood pressure reductions (3-7 mmHg), improved lipid parameters, and a small increase in resting heart rate (2-4 bpm)