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A., The Journal of Physical Chemistry A , 2003 , 107 , 4184
In adjusted analyses, semaglutide reduced epigenetic aging across multiple second- and third-generation clocks, including PhenoAge ( 4.9 years/year, p = 0.004), PCGrimAge ( 3.1, p = 0.007), GrimAge V2 ( 2.3, p = 0.009), OMICmAge ( 2.2, p = 0.009), RetroAge ( 2.2, p = 0.030), and DunedinPACE ( 0.09 units, 9% slower, p = 0.01)
The inclusion criteria encompassed English-language publications or publications with an English translation available, including conference abstracts, observational studies, randomized controlled trials (RCTs) and meta-analyses
Theoretical (mechanistic): the HGF/c-Met pathway governs growth, proliferation, and angiogenesis and is dysregulated in some cancers, so chronic potentiation raises a theoretical oncological concern
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