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In the hour-long TV special that Oprah hosted, set on a stage reminiscent of her iconic talk show, the talk show icon said, I took on the shame that the world gave to me

Scientists believe the drugs may dampen dopamine-related reward pathways in the brain that help shape cravings and compulsive behavior

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Evidence that many people may stop their use of obesity drugs not long after starting therapy casts doubt about the sustainability of weight loss to achieve long-term positive health outcomes

As their use has expanded, questions about long-term safety have emerged, particularly regarding potential cancer risk

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