Caloric restriction and its mimetics produce much greater percent increases in lifespan in mice (2 year lifespan) compared to dogs (10 yrs) or monkeys or humans
doi: 10.1093/eurheartj/ehz486 [PubMed] [CrossRef] [Google Scholar] Joseph J.J., et al., Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
DSIP, in contrast, appears to facilitate sleep initiation and depth via slow-wave promotion rather than wakefulness suppression
Endotoxin testing should show levels below safe thresholds for injection
For example, specific formulations have been investigated for nasal drug delivery, such as soft nano-vesicular systems, microsphere/inert carrier dry powder platform for brain-targeted delivery, and binary composite solid microparticles as nasal permeation enhancers ( per se are able to internalize live cells and are peptide enhancers that mediate the transepithelial transport of large molecules without affecting cellular integrity
No high-quality clinical trial has demonstrated that B12 injections produce meaningful weight loss outcomes independent of dietary and exercise changes
