Abstract Recent large clinical trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, with the aim of verifying cardiovascular safety, have revealed that these medications have a preventative advantage on adverse cardiovascular outcomes, including worsening of heart failure and deterioration of nephropathy, in patients with type 2 diabetes (T2D)
Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease
Moreover, in a lean mouse model of severe nonalcoholic fatty liver disease, phosphatidylethanolamine N -methyltransferase mice, we observed a 4-fold increase in circulating DPP4, in contrast with previous findings connecting DPP4 release and obesity
Incretin-based therapy of metabolic disease Abstract Incretin-based therapy of metabolic disease Recent studies show that incretin hormone analogues effectively control blood glucose while producing major weight losses and reducing the risk of all-cause mortality, myocardial infarction, stroke and kidney function impairment
Unfortunately, kidney function tends to decline as we get older, so that older people have a weakened ability to rid their bodies of many toxins
But the proposed approach, outlined in the journal Molecular Metabolism by some of the most well-known scientists in the field, is likely to stir controversy, as it challenges a central notion underpinning not just the development of approved obesity products but also next-generation versions