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Naunyn-Schmiedebergs Arch Pharmacol
It was only recognized in the late 1980s that desensitization of insulin secretion, which describes a state of decreased secretory responsiveness of -cell to the glucose stimuli, is a pathophysiological phenomenon of -cell function and not just an in vitro artifact 30
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IGF binds to its cell surface receptors such as type I insulin-like growth factor receptor (IGF-IR) and then initiates multiple signaling pathways including PI3K/Akt, MAPK, JAK/STAT, Src, and focal adhesion kinase (FAK), which act in concert to stimulate cancer cell proliferation, survival and migration
2011;6(3):e17971 [9] Jiang X, Tian Q, Wang Y, Zhou XW, Xie JZ, Wang JZ, Zhu LQ.Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C
