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The science behind Ozempic The active ingredient in Ozempic, semaglutide, is a GLP-1 receptor agonist that mimics a naturally occurring hormone in the body

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In the landmark SURPASS-2 trial published in the New England Journal of Medicine, tirzepatide at its highest dose (15 mg) achieved roughly double the weight reduction of semaglutide 1 mg at 40 weeks