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Much of the focus on the impact of GLP-1 receptor agonists (and combination drugs with components that target other receptors such as gastric inhibitory polypeptide collectively termed GLP-1s in this article) to date has been on their potential to improve long-term health outcomes for people with type 2 diabetes, obesity, and related cardiovascular diseases

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Therefore, the first amide bond between (2 S ,3 S )- t -ES and l-Ile is catalyzed by Cp1B, while formation of the second amide bond between 14 and putrescine is catalyzed by Cp1D (Fig

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