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Glucuronidation: UGTs catalyze an SN2 nucleophilic substitution where the substrate's nucleophilic functional group (OH, NH2, SH, COOH) attacks the C1 carbon of glucuronic acid in UDPGA, displacing UDP

For context, many peptides show strong receptor activation in vitro but fail to produce clinical effects because they cannot be delivered at effective concentrations in living organisms

This is precisely why its the gold standard for reconstituting medications or peptides that will be used more than once from the same vial

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