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additive risk unknown | | Long-term pituitary desensitization | Not characterized | Not characterized | | Carcinogenesis | No human data

The original approved version was discontinued in 2008 for commercial reasons, not safety concerns

metformin 1000 mg BID in PCOS women with obesity that have been previously reported, also evaluated the efficacy on glucose metabolism [57, 58]

As with generics, biosimilars are often less expensive compared with brand-name medications

This characteristic can be beneficial in studies focused on stress hormone balance and its implications for recovery and body composition