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Cardiovascular disease risk in SLE is markedly raised compared to the general population, and weight gain itself can compound joint pain, fatigue, and low mood
It highlights its ability to enhance lipolysis, preserve muscle mass, and activate fat breakdown mechanisms through IGF-1 receptor pathways
Additionally, studies have shown that antioxidant enzymes GPX4 and SOD1, along with the transcription factor NRF2, are involved in intracellular GSH redox reactions [29, 30]
Glutathione is generally well-tolerated but can cause mild gastrointestinal side effects and, possibly, skin flushing
This can lead to fewer cravings, smaller meal portions, less food noise or preoccupation with food in your head, better insulin sensitivity, and improved gut health
These should be considered if tiredness persists despite managing GLP-1-related factors
