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10.1007/s12975-014-0365-7 162

Do not squirt the liquid forcefully

In DUAL-1 the A1c reduction from baseline with IDegLira was somewhat higher (estimated difference of 0.21%) in patients in use of pioglitazone and metformin compared to those with metformin alone (A1c for IDegLira 1.8% in the metformin subgroup and 2.1% in the metformin plus pioglitazone subgroup

Some researchers also track NAD+ metabolite levels via urinary nicotinamide excretion to confirm functional NNMT inhibition, though this is not standard practice

Keep the vial in its original packaging to protect it from light

Bassim CW, Gautam P, Domingo DL, Balog JZ, Guadagnini JP, Gahl WA, Hart TC (2010) Craniofacial and dental findings in cystinosis