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doi: 10.3390/microorganisms8010139, 32

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Together they stimulate the body's endogenous growth hormone production without introducing exogenous hormones, a mechanism relevant to perimenopausal women because GH levels decline in parallel with estrogen, compounding symptoms like poor sleep, abdominal fat accumulation, and reduced lean mass

"Efficacy and Safety of Rezm System Water Vapor Treatment for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia"

doi: 10.1186/s12937-020-00604-1 76

For research-context systemic use, cycles of 4 to 12 weeks with breaks are a common protocol in the compounded peptide space, but this is convention, not evidence-based guidance