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Mutations in TREM2 impair microglial function, leading to reduced clearance of amyloid plaques as well as a pro-inflammatory state that tends to exacerbate neuronal damage (Li et al., 2023)
Nilsson K, Giovanella BC, Stehlin JS, Klein G
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Individual responses to retatrutide vary based on genetics, metabolic health, diet, exercise, stress, sleep, and other factors