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The slow build-up helps reduce both the likelihood and the intensity of side effects, such as nausea, which is common early on with GLP1 medicines
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a randomized CCTA trial addressing this question remains an evidence gap
These data are supported by a recent meta-analysis of 17 trials that included 2,851 patients: the study concluded that cryotherapy reduced the incidence of CIPN and improved quality of life for cancer patients (Tai 2024)
These findings are consistent with improvement in cognitive performance and BPSD in prior placebo-controlled studies with NF, and contrast with the routine decline for participants receiving placebo. Cuturic, M, et al Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. in Journal of Psychiatric Practice
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