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Another meta-analysis of the same seven trials similarly reported that GLP-1RAs significantly reduced MACE, with a number needed to treat (NNT) to prevent one MACE of 73 (95% CI 45212) ( Reasons that have been postulated to account for the lack of positive effect in the ELIXA trial are the different trial populations (such that biological processes after an acute coronary event may be less amenable to modification than those relating to general atherosclerosis) and the short duration of action of lixisenatide (insufficient GLP-1 receptor stimulation over the 24-hour dosing period) ( What Is the Place of GLP-1RAS in the Guidelines for Patients With Diabetes and Cardiovascular Disease

In short, you may crave sugar because your mind and body have been trained to crave it

Ongoing guidance : Starting new medication while overhauling your eating habits can feel overwhelming

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