Use of GLP-1 RAs is limited by high cost, which creates disparities those who cannot afford these drugs may miss out on the benefits
Several studies have identified various sources of ROS and RNS in IBD, including neutrophils, macrophages, and inflamed intestinal tissue ( 2 Mechanism of oxidative stress in IBD While the precise mechanisms responsible for the development of IBD remain unclear, it is widely accepted that multiple factors contribute to its etiology, including overproduction of ROS, damage to biomolecules, mitochondrial dysfunction, recruitment of immune cells, impaired antioxidant defense system, and the activation of inflammatory pathways ( Figure 1 )
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TABLE 3 Overview of algorithms utilized for signal detection
As an added advantage, GLP-1s are not themselves addictive and don't trigger withdrawal
Journal of Clinical Investigation , 132(10), e149248