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The presence of the specialized tripeptide KPV allows researchers to monitor the competitive downregulation of nuclear factor kappa B (NF-kB) and trace the inhibition of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) within inflamed intestinal or cutaneous tissues
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Likewise, the lead compounds overcame the blockage of cholesterol export induced by pharmacological inhibition of NPC1 in differentiated SH-SY5Y neuronal cells and 3D-brain organoids
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