increased anxiety on glp 1 GLP-1 and Anxiety: Clinical Insights (public) GLP-1 Agonists Can Be Heaven

Several studies suggest that similar to lipids, reductions in food intake via intestinal protein in rodents are due to CCK release and subsequent activation of VANs, as (1) intestinal protein infusion increases CCK in rodents and humans 188,189

Weight Loss Maintenance : GLP-1 medications have been shown to support ongoing weight loss efforts and help maintain weight loss over time

Some worry these drugs bypass deeper issues

Routes Subcutaneous (SubQ) injection and topical formulations are the two main research-use routes

Given the recognized window of opportunity in early PsA, future research should prioritize trials in patients with subclinical joint involvement, arthralgia, or early enthesitis, especially those with coexisting obesity or MetS

Most pharmacokinetic studies assessing the brain uptake of incretin mimetics have been conducted in animals, and translating these findings to human subjects and clinical outcomes remains uncertain